Lady Henrietta Frances Spencer
- Born: 16 Jun 1761, Althorp Manor, Brington, NTH
- Marriage: Frederick Ponsonby 3rd. Earl of Bessborough on 27 Nov 1780 in St. James's, Westminster, MDX
- Died: 11 Nov 1821, Italy aged 60
- Buried: 29 Dec 1821, All Saints, Derby, DBY
Henrietta married Frederick Ponsonby 3rd. Earl of Bessborough, son of William Ponsonby 2nd. Earl of Bessborough and Caroline Cavendish, on 27 Nov 1780 in St. James's, Westminster, MDX. (Frederick Ponsonby 3rd. Earl of Bessborough was born on 24 Jan 1758 in Bessborough, IRE and died on 3 Feb 1844.)
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